New Treatment Capabilities
RefleXion offers a fundamental innovation in biology-guided radiotherapy, using the biological characteristics of the cancer in real-time as a signal to guide simultaneous treatment of tumors throughout the body.
Building from Positron Emission Tomography
Positron emission tomography (PET) is an established imaging standard in cancer detection, offering high sensitivity and specificity compared to other imaging modalities across the majority of cancer types.
Until now, images used in radiation oncology (including CT and MRI) are largely structural, whereas PET images can provide biological insights. By using injectable tracers, such as fluorodeoxyglucose (FDG) radiolabeled with fluorine-18, PET can depict the metabolic activity of tumors, causing them to “light up”. Alternative PET tracers can identify other distinct biological characteristics of tumors such as specific biomarker antigens (e.g., PSMA) or even probe the immune system itself (e.g., PDL1 expression or activated T-cells).
FDG is the most widely used tracer for visualizing cancer metabolism. Tumor cells retain higher levels of FDG when compared to normal tissue.
RefleXion uses the coincident PET photon pairs to guide the beam for time-efficient biological guidance
PET & Radiotherapy Combined at the Time of Treatment
RefleXion combines PET imaging with stereotactic radiotherapy for superior localization and tracking at the time of treatment delivery. Tumors will continuously signal their location and activity levels during treatment, effectively making FDG a theranostic and revolutionizing the practice of radiation oncology in the process.
With so much potential, why hasn’t it been done before? One reason is that it can take minutes to generate a reasonable quality image using conventional PET technology, making it unsuitable to track motion caused by respiration and other bodily functions.
To circumvent the slow image acquisition time of PET, RefleXion’s patented technology uses the coincident PET photon pairs to guide the radiotherapy treatment beam as the emitted photons are detected in real-time, providing a time-efficient method for biological guidance.